Keto brain fog11/14/2023 Neurocognitive abilities are essential for humans to interact with their surrounding environment and acquiring these abilities is a progressive process thus, advancement in cognitive functioning mirrors normal neurodevelopmental changes beginning in infancy and early childhood, up to older adulthood, where regressive changes (structural and functional) may occur and may impact some of the previously acquired cognitive abilities. The brain’s functional sophistication is not constrained to motor movements and autonomic regulations-higher neurocognitive functions needed for learning processes, social skills, and interactive situations are also functionally relevant. Thus, efforts to tackle the growing number of cognition-impairing diseases and conditions are of public health importance high-quality research efforts addressing cognitive impairment are necessary.įunctionality of the normal brain is essential for optimizing activities of daily living. This ominous trend is also predicted for MCI with estimated cases expected to be double the number of AD in the United States. Moreover, the projected number of AD cases is expected to steadily increase to 13.9 million by the year 2060. In 2021, AD was estimated to affect around 6.25 million people living in the United States. Moreover, the burden of cognitive deterioration in conditions such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI) extend beyond the individual to include caregivers and the entire healthcare system. Neurophysiological changes of the cognitive brain in response to ketosis through neuroimaging modalities are also described in this review to provide insight into the ketogenic effect on the brain outside the framework of purely molecular explanations.Īlteration of normally acquired cognitive function has a significant impact on the affected individual’s life. In this review, we describe the potential of ketogenic approaches to produce cognitive benefits in healthy individuals, as well as those with MCI and AD. Ketone bodies are an efficient alternate fuel source that could compensate for the deficient glycolytic metabolism upon their supra-physiologic availability in the blood (ketosis), which, in turn, could promote cognitive benefits and tackle disease progression. Glucose is the core source of bioenergy in the body however, glucose brain metabolism could be affected in aging cells or due to disease development. Various dietary and nutritional approaches have potential for promising results in managing cognitive deterioration. Cases of AD and its milder subset, mild cognitive impairment (MCI), are rising and would impose a burdensome impact beyond the individual level. Cognitive abilities are acquired during early childhood as part of progressive neurodevelopmental milestones unfortunately, regressive changes can occur as part of physiological aging, or more ominously, pathological diseases, such as Alzheimer’s disease (AD). Optimal cognitive functions are necessary for activities of daily living and self-independence.
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